The main campus in Fullerton consists of six buildings: the Administration Building, the Basic and Clinical Sciences Building, Warren and Carol Low Student Union, the Health Professions Building, Campus Safety/Operations/Parking Structure, and the Richard L. Hopping Academic Center.

The University owns and operates two teaching clinics; the University Eye Center at Los Angeles located in South Los Angeles and the University Eye Center at Ketchum Health located in Anaheim. Ketchum Health Anaheim also houses the SPAS Family Medicine practice and the COP Pharmaceutical Sciences Research Laboratory, which allows collaborative practice between all three professions.